Case Studies and Other Resources

Case studies are descriptions of alternatives assessments that have been conducted by manufacturers, academic institutions, NGOs or government bodies. The search feature below may be used to identify case studies of greatest relevance to your substitution or alternatives assessment goals. You may also view more in-depth information on each case study by clicking the "View Full Summary" button. For details on how case studies were selected and summarized, please visit the Case Studies Methodology page.

Additional compilations of completed alternatives assessments include (but are not limited to) the following resources:

CAS Number
Industry Sector
Technical Function

Number of case studies shown: of (Show All)

Toolkits are websites that contain a variety of information related to safer chemical substitutions and alternatives assessments.

Organization Toolkit Name Description
ChemHATChemical Hazard and Alternatives ToolboxAn internet portal containing information about hazardous chemicals and safer alternatives, focusing on workplace safety, and includes a searchable chemical hazard database
ANSES (French Agency for Food, Environmental and Occupational Health & Safety) and INRS (French Institute for Research and Security)A Tool to Support the Substitution of CMR SubstancesThis French website was developed by ANSES and INRS. This website focuses on CMR chemicals, and is a database for information about these chemicals and a database for chemical alternatives for CMR. The alternatives database is compiled from industry experience, research and data found in the literature.
French National Institute for Industrial Safety and Environment Protection (INERIS)National Helpdesk: Chemicals SubstitutionThis tool is a repository of case studies, relevant regulations, current news, and potential alternatives to bisphenols and phthalates.
Green Chemistry & Commerce Council (GC3)GC3 Retailer PortalA database of tools that enable retailers to evaluate chemicals or chemical-containing products for their potential human health and environmental impacts
Health Care Without HarmNurses Safer Chemicals ToolkitDeveloped by Health Care Without Harm in conjunction with the Nurses Workgroup to address health risks of hazardous chemicals
Occupational Safety & Health Administration (OSHA)Transitioning to Safer ChemicalsA step-by-step toolkit developed by the OSHA to provide employers and workers with information, methods, tools, and guidance on using informed substitution in the workplace
State of Washington Department of EcologyWaste & Toxics InitiativeAs part of its Waste & Toxics Initiative, the Department of Ecology has compiled various sources of information on selecting safer chemical alternatives
SUBSPORTSubstitution Support Portal (SUBSPORT)A web-based portal containing information on substituting safer chemicals for hazardous ones: substitution steps, legislation (EU), hazardous chemical databases, substitution tools and case studies
ECHA: European Chemicals AgencyAdopted opinions and previous consultations on applications for authorisationThis tool is a repository of applications for authorization to start or continue using a substance submitted to the ECHA’s Committees, including a variety of substances, uses, and the decision made by the Commission. The application for authorization includes an Analysis of Alternatives.
ECHA: European Chemicals AgencyAdopted opinions on restriction proposalsAnalysis of alternatives performed in the context of REACH restriction proposals. Restrictions limit or ban the manufacture or use of substances in the EU that pose risks to human health and the environment.
EcoValuateEcoValuate Alternatives Assessment Software ©This tool allows users to visually evaluate complex information about environmental constraints involved in alternatives assessments and alternative product development strategies.
IRSST (Quebec Occupational Health and Safety Research Institute Robert-Sauve)Solub, Solvent Substitution Process in the WorkplaceThe French website Solub proposes a systematic workplace solvent substitution process. It is intended for health and safety professionals who want to carry out an organic solvent substitution project. This substitution process may lead to the implementation of a solution adapted to the user’s workplace. The site also proposes practical tools, relevant resources and concrete examples.

Consumers and purchasers concerned about chemical safety of products in the marketplace often seek an authoritative product rating or labeling system to help them guide their purchases. The resources below are databases and labeling systems that evaluate products based on chemical safety and sustainability characteristics.

Organization System Name Description
U.S. EPA's Design for the Environment (DfE) Branch Safer Choice Program The U.S. EPA’s Safer Choice Program helps businesses, consumers, and institutional buyers identify cleaning and other products that have met stringent criteria for health and environmental safety. The Safer Choice label on a product means that the EPA scientific review team has screened each ingredient for potential human health and environmental effects and that — based on the best currently available information, EPA predictive models, and expert judgment — the product contains only those ingredients that pose the least concern among chemicals in their class. A list of chemicals that have met the Safer Choice standard is available on EPA’s Safer Chemical Ingredient List (SCIL).
Healthy Buildings NetworkPharos ProjectThis data source is for building materials evaluations and is divided into three parts: building materials library, chemical/materials library and certification information. The building materials library contains products that are scored in 5 categories (see Hazard Endpoints) separately (no aggregate score). The chemical and materials library rates each entry on individual health and environmental impacts of throughout their lifecycle (if applicable) – no aggregate score. Also, not every entry contains comprehensive data. Pharos also contains a database of second and third party certifications and identifies building products that have been certified; certification is one criterion in the scoring system.
GreenBlue®CleanGredients®CleanGredients® was developed by GreenBlue® to help cleaning product formulators identify environmentally friendly ingredients and allow manufacturers to showcase their ingredients. CleanGredients® is a subscription-based online database with 12 cleaning product ingredient categories: chelating agents, colorants, defoamers, enzymes, fragrances, oxidants, polymers, preservatives and antioxidants, processing aids, solvents, starter formulations, and surfactants. Non-subscribers have partial access to website information. Ingredient formulation and attribute claims are verified by an approved third-party.
Cradle to Cradle Certified Products RegistryCradle to Cradle Products Innovation InstituteThis tool is a database of products that have been certified as “sustainable” being evaluated against 5 categories. An aggregated score is calculated. The products are ranked using five ranking categories: platinum, gold, silver, bronze and basic for each categorical score. Each of the 5 impact categories are ranked and an overall ranking is calculated.