OECD Substitution and Alternatives Assessment Tool Selector

The Tool Selector is designed to provide information on tools that can be used in conducting chemical substitutions or alternatives assessments. The filters below may be used to identify tools of greatest relevance to your substitution or alternatives assessment goals. You may also view more in-depth information on each tool, or a side-by-side comparison of a set of tools, by selecting two or more tools from the list below.

All tools included in the Tool Selector address chemical hazard assessment, and may address other comparative attributes.

tools icon What's an Alternatives Assessment Tool?

A tool is an approach for evaluating a chemical, material, process, product, and/or technology for attribute analysis within a chemical substitution/alternatives assessment.

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frameworks icon How Were the Tools Scored?

For details on how the tools were identified and scored for the Tool Selector, please visit the Methodology page.

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Tools that contain a repository of organized information but do not have a mechanism for data manipulation for outside users are flagged below as data sources using the following symbol: Data Source

For information on tools with a primary focus on non-hazard comparative attributes such as cost/benefits and availability, life-cycle impacts, and materials management, please visit the Inventory of Non-Hazard Assessment Tools.

Each tool has its benefits and limitations. The user of this toolbox needs to understand the capabilities of the tools to make the most informed decisions about conducting alternatives assessments.

For details on how the tools were identified and scored for the Tool Selector, please visit the Tool Selector Methodology page.

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List of Tools


CAMEO Chemicals ( Summary | Tool Website ) Data Source

CAMEO Chemicals is a database of hazardous chemicals that contain safety and exposure information for emergency responders and planners so they can use to get response recommendations and predict hazards, such as explosions, chemical fires and predicted results from chemical mixtures. It is part of the CAMEO software suite and is available in both online and desktop versions.


Chemical Entities of Biological Interest (ChEBI) ( Summary | Tool Website ) Data Source

Chemical Entities of Biological Interest (ChEBI) is a database of molecular entities focused on ‘small’ chemical compounds with potential pharmacological properties. The database consists of records including products of nature or synthetic products used to intervene in the processes of living organisms.


Chemicalize.org ( Summary | Tool Website ) Data Source

Chemicalize.org was developed by ChemAxon and contains structural and physiochemical data on chemicals, which includes molecular properties.


ChemicALL ( Summary | Tool Website ) Data Source

Chemicall is a database of hazardous chemicals used by members of the Swedish Chemicals Group in the electronics and textile industries. All chemicals contained in the database have been identified as hazardous per authoritative sources. Chemicall also identifies human health and environmental impacts, as well as authoritative "chemicals of concern" lists that contain a specific chemical.


ChemSpider ( Summary | Tool Website ) Data Source

ChemSpider is a free chemical structure database providing information on over 32 million structures from 490 data sources. Data source contains small internal database, but provides links to comprehensive information.


ChemView ( Summary | Tool Website ) Data Source

EPA developed ChemView in 2013 to increase the availability of information on chemicals in order to strengthen the existing chemicals program and improve access to and usefulness of chemical data and information. ChemView assists users in getting information on chemical health and safety data and on EPA’s assessments and regulatory actions for specific chemicals under the Toxic Substances Control Act (TSCA). It also contains information EPA receives and develops about chemicals that end up on EPA’s Safer Chemical Ingredients List.


CleanGredients® ( Summary | Tool Website ) Data Source

CleanGredients® was developed by GreenBlue® to help cleaning product formulators identify environmentally friendly ingredients and allow manufacturers to showcase their ingredients. CleanGredients® is a subscription-based online database with 12 cleaning product ingredient categories: chelating agents, colorants, defoamers, enzymes, fragrances, oxidants, polymers, preservatives and antioxidants, processing aids, solvents, starter formulations, and surfactants. Non-subscribers have partial access to website information. Ingredient formulation and attribute claims are verified by an approved third-party.


Column Model ( Summary | Tool Website )

The Column Model was developed by the Institute for Occupational Safety and Health (IFA) of the German Social Accident Insurance as a tool for industry for identifying alternative substances. The tool allows for the comparison on chemicals/substances or materials/mixtures based on six hazard endpoints. Endpoints are compared individually and collectively, and the user makes the final evaluation.


Compendium of Common Pesticide Names ( Summary | Tool Website ) Data Source

For purposes of trade, registration and legislation, and for use in popular and scientific publications, pesticides need names that are short, distinctive, non-proprietary and widely-accepted. More than 1100 of these official common names for pesticides have been assigned by the International Organization for Standardization (ISO). This Compendium is believed to be the only place where all of the ISO-approved standard names of chemical pesticides are listed. The Compendium contains much more than ISO common names, with nomenclature data sheets for more than 1700 different active ingredients and for more than 350 ester and salt derivatives.


DrugBank ( Summary | Tool Website ) Data Source

The DrugBank database provides records on "small" chemicals with potential pharmacological or bioactive properties. The database contains 7740 drug entries including 1584 FDA-approved small molecule drugs, 157 FDA-approved biotech (protein/peptide) drugs, 89 nutraceuticals and over 6000 experimental drugs.


eChemPortal ( Summary | Tool Website ) Data Source

A searchable database for obtaining many properties of chemicals: physiochemical properties, toxicity, ecotoxicity, and environmental fate/pathways. The first tier of results provides references to external data. The user must access these external sources for data.


ECOTOX ( Summary | Tool Website ) Data Source

The ECOTOX database combines three previously independent databases (AQUIRE, PHYTOTOX, and TERRETOX) into a single resource for chemical toxicity information on aquatic life, terrestrial plants, and terrestrial wildlife.


EPA's Substance Registry Service Database ( Summary | Tool Website ) Data Source

EPA's Substance Registry Service Database makes it possible to identify which EPA data systems, environmental statutes, or other sources have information about a substance and which synonym is used by that system or statute. It becomes possible therefore to map substance data across EPA programs regardless of synonym.


GESTIS Substance Database ( Summary | Tool Website ) Data Source

The GESTIS-Substance Database was developed by the Institute for Occupational Safety and Health of the German Social Accident Insurance in Sankt Augustin/Germy and contains information on toxicological, ecotoxicological, physiochemical properties, occupational health/first aid, handling/usage and associated European regulations.


Granta ( Summary | Tool Website ) Data Source

This is a tool for materials selection and includes information on physio-chemical and engineering properties, processing, environmental impacts, costs and performance; life cycle impacts can also be evaluated. This tool also contains a database of restricted substances that was developed by NGOs, governments and industry. Materials selection information is contained in several different modules.


Green Chemistry Assistant ( Summary | Tool Website )

The Green Chemistry Assistant allows users to manipulate and assess chemical reactions by determining atom economy, limiting reactant, theoretical yield, percent yield, and comparing chemical safety data. This tool is based on U.S. EPA's Green Chemistry Expert System SMART Module.


GreenScreen® for Safer Chemicals ( Summary | Tool Website )

GreenScreen® was developed by Clean Production Action to support the transition to safer chemicals and to support more informed decision-making on the use of chemicals in products and processes. GreenScreen® provides a rigorous comparative hazard assessment for evaluating alternatives to chemicals of concern based upon 18 hazard endpoints.


GreenScreen® List Translator (GSLT) ( Summary | Tool Website )

GSLT was developed by Clean Production Action as a rapid screening assessment tool for chemical substances. The screening evaluation results in three outcomes: of high concern, possibly of high concern, and unknown. GSLT is meant to prioritize chemicals for a more comprehensive assessment using the full GreenScreen® method.


Hazardous Chemicals in Schools Database ( Summary | Tool Website ) Data Source

The Hazardous Chemicals in Schools Database was developed by the Local Hazardous Waste Management Program in King County, WA, primarily for the handling of hazardous chemicals commonly used in schools, this online tool provides information to assess risks and inventory chemicals. Find the chemical by name, the exposure and safety hazards, environmental toxicity, and common experiments that may utilize the chemical.


Haz-Map ( Summary | Tool Website ) Data Source

Haz-Map is an occupational health database designed for health and safety professionals and for consumers seeking information about the adverse effects of workplace exposures to chemical and biological agents. Chemical records include formula, synonyms, description, uses, exposure assessment, adverse effects, and links to TOXNET and ChemIDplus.


Integrated Risk Information System (IRIS) ( Summary | Tool Website ) Data Source

EPA's Integrated Risk Information System (IRIS) is a human health assessment program that evaluates information on health effects (cancerous and non-cancerous) that may result from exposure to environmental contaminants. The IRIS database contains information that can be used to support the first two steps (hazard identification and dose-response evaluation) of the risk assessment process.


IPCS INCHEM ( Summary | Tool Website ) Data Source

IPCS INCHEM was developed by IOMC and consolidates current, internationally peer-reviewed chemical safety-related publications and database records from international bodies for public access.


KemI PRIO ( Summary | Tool Website )

PRIO was developed by the Swedish Chemical Inspectorate (KemI) to help eliminate high hazard chemicals from products to meet the Swedish government's goal of a "non-toxic environment" by 2020. PRIO contains a database of chemicals of high concern to human health and the environment, which are divided into "phase-out" or "priority risk reduction" chemicals. “Phase-out” chemicals should be avoided or substituted, and the tool provides a seven step process for identifying safer alternatives. For “priority risk reduction” chemicals, further assessments are recommended to ensure risk minimization.


MaterialIQ ( Summary | Tool Website )

MaterialIQ was developed to serve as a product design tool and as a product database of third party certified products. Users can select different methods for human health and ecotoxicity evaluations: GreenScreen List Translator, Scivera Lens or GreenScreen. Product evaluations can also be designed per criteria of a specific ecolabel. MaterialIQ was developed to improve transparency of hazard material usage throughout the supply chain.


OncoLogic 8.0 ( Summary | Tool Website )

OncoLogic 8.0 is a Windows software tool that predicts the potential carcinogenicity of metals, polymers, fibers, and organic chemicals. Evaluation is based upon structure activity relationship (SAR) analysis and a compilation of cancer data on 1,500 chemicals. This tool is intended to provide data on chemicals for which little or none exists.


OSHA Occupational Chemical Database ( Summary | Tool Website ) Data Source

The OSHA Occupational Chemical Database was developed by OSHA and EPA as a convenient reference for the occupational safety and health community. It compiles information from several government agencies and organizations. Information available in the report includes physical properties, exposure, worker safety data, and emergency response information.


Pharos Project ( Summary | Tool Website ) Data Source

This datasource is for building materials evaluations, and is divided into three parts: building materials library, chemical/materials library and certification information. The building materials library contains products that are scored in 5 categories (see Hazard Endpoints) separately (no aggregate score). The chemical and materials library rates each entry on individual health and environmental impacts throughout their lifecycle (if applicable). However, no aggregate score is calculated. Also, not every entry contains comprehensive data. Pharos also contains a searchable database of second and third party certifications and identifies building products that have been certified; certification is one criterion in the scoring system.


Pollution Prevention Options Analysis System (P2OASys) ( Summary | Tool Website )

P2OASys was developed by the Toxic Use Reduction Institute (TURI) at the University of Massachussetts, Lowell to help companies assess unforeseen consequences of current alternative technologies. P2OAsys allows companies to assess environmental, worker, and public health impacts from alternative technologies. The tool automatically compares current processes to alternatives based on 11 endpoints using an aggregated score, which is dependent upon the proportion of chemical present.


Program for Assisting the Replacement of Industrial Solvents (PARIS) III ( Summary | Tool Website )

PARIS III was developed by the United States Environmental Protection Agency as a software tool to assist users in finding mixtures of solvents with specific properties that have reduced environmental impacts. Many solvents currently used in industrial processes have negative environmental impacts. PARIS III is designed to encourage technicians, engineers, and consultants to add more benign solvents to harmful ones to reduce the overall environmental impact without the need for equipment updates.


Quick Chemical Assessment Tool (QCAT) ( Summary | Tool Website )

Using GreenScreen® as a blueprint, QCAT was developed by the Washington State Department of Ecology to function as a simpler tool for smaller businesses. QCAT is a screening tool for evaluating chemicals/substances to determine their degree of toxicity and assess alternatives. Chemicals are rated based on an aggregated score of nine hazard endpoints, but relative toxicities can also be assessed based on individual endpoints.


RISCTOX ( Summary | Tool Website ) Data Source

RISCTOX was developed by the Spanish Trade Union Institute of Health, Work and Environment (ISTAS) and the European Trade Union Institute (ETUI) and is based on European environmental and health standards. The tool includes over 100,000 chemicals, providing information on substance classification and labeling under EU Regulation 1272/2008, health and environmental impacts and risks, and environmental and health regulations. Users can search by hazard endpoint or specific substance.


Safer Chemical Ingredients List (SCIL) ( Summary | Tool Website ) Data Source

The U.S. EPA’s Safer Choice program helps businesses and consumers make better purchasing decisions by labeling products that have been screened using stringent criteria for health and environmental safety. The SCIL website lists chemicals that meet the criteria of the Safer Choice program. This list of safer chemical ingredients is arranged by 15 functional-use classes and can assist product manufacturers in identifying chemicals that the Safer Choice program has already evaluated and identified as safer. A list of products with the Safer Choice label, organized by consumer and Industrial and Institutional product categories, can also be assessed from the SCIL website.


SCIVERA LENS Chemical Safety Assessment System ( Summary | Tool Website )

This tool provides automated restricted substance list (RSL) review, hazard evaluation, exposure assessment (human health and environmental) and risk assessment over the life cycle of the product. As a tool for an alternatives assessment, user can process potential substitutes through the RSL, hazard, exposure, and risk steps to identify preferred alternatives. Scivera was developed for secure supplier product chemical data collection and comprehensive product evaluation.


SIN List and SINimilarity ( Summary | Tool Website )

The SIN List is an NGO List suggesting substances fulfilling REACH criteria for being “Substances of Very High Concern” (SVHCs). To date, the SIN List consists of some 800 CAS numbers divided into 31 groups. In the SIN List database, for every substance, there is information on hazardous properties, EU regulatory status, producing companies and production volume. When applicable, it also links to substitution case stories. SINimilarity is available through the SIN List database and can identify substances that are structurally similar to SIN List substances. The tool indicates whether the searched substance contains the same group-specific structural elements as SIN List substances and/or if it has structural similarity to any SIN List substances. SINimilarity includes a reference database of 80,000 substances that have been pre-registered under REACH.


SubSelect ( Summary | Tool Website )

The German Federal Environmental Agency's “Guide on Sustainable Chemicals” helps manufacturers, formulators, or end users of substances to put a greater emphasis on sustainability aspects in the selection of substances and use of chemicals. The guide furthermore assists companies in the implementation of the REACH task on the safe use of substances. With the Access-based file SubSelect, an electronic version of the guide is now available. SubSelect assists users in evaluating the sustainability of substances and mixtures.


TOXNET ( Summary | Tool Website ) Data Source

TOXNET is a comprehensive collection of databases managed by the National Institute of Health that provide data and references for hundreds of thousands of potentially hazardous chemicals. Entering a chemical ID or associated hazards into the search field cross-references and returns results from the following databases: TOXLINE, ChemIDplus, Developmental and Reproductive Toxicology Database (DART), Carcinogenic Potency Database (CPDB), GENE-TOX, Comparative Toxicogenomics Database (CTD), Chemical Carcinogenesis Research Information System (CCRIS), and International Toxicity Estimates for Risk (ITER).


UL The Wercs ( Summary | Tool Website )

UL The Wercs is a screening tool for product evaluation. The evaluation can be as complex as the user desires as the user selects the type and number of hazard endpoints/impacts to be evaluated: the user tailors the model. Multiple products can be compared graphically. The tool evaluates the products based on the presence of “chemicals of concern” in the product. The basis of chemicals of concern are “authoritative lists” or restricted substance lists developed by industry.


ZINC12 ( Summary | Tool Website ) Data Source

ZINC12 was developed by the University of California, San Francisco and is a database of chemical and structural properties consisting of over 35 million compounds that can be screened for biological relevance. ZINC12 includes over 200 catalogs from over 100 vendors and over 40 annotated catalogs.

Tool Name Overall Applicability Goals Chemical Hazard Attributes Other Comparative Attributes User-Friendliness Fees User Expertise
CAMEO Chemicals
Chemical Entities of Biological Interest (ChEBI)
Column Model
Compendium of Common Pesticide Names
EPA's Substance Registry Service Database
GESTIS Substance Database
Green Chemistry Assistant
GreenScreen® for Safer Chemicals
GreenScreen® List Translator (GSLT)
Hazardous Chemicals in Schools Database
Integrated Risk Information System (IRIS)
OncoLogic 8.0
OSHA Occupational Chemical Database
Pharos Project
Pollution Prevention Options Analysis System (P2OASys)
Program for Assisting the Replacement of Industrial Solvents (PARIS) III
Quick Chemical Assessment Tool (QCAT)
Safer Chemical Ingredients List (SCIL)
SCIVERA LENS Chemical Safety Assessment System
SIN List and SINimilarity
UL The Wercs

Note: a grey box indicates that the filter category was not selected as part of the filter criteria