OECD Substitution and Alternatives Assessment Tool Selector

The Tool Selector is designed to provide information on online resources and software that can be used in conducting chemical substitutions or alternatives assessments. The Tool Selector is divided into two categories: tools, which provide users with the ability to evaluate a chemical, material, process, product and/or technology for attribute analysis with

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an alternatives assessment, and data sources, which contain a repository of organized information but no mechanism for data manipulation for outside users.

The filters below may be used to identify tools and data sources of greatest relevance to your substitution or alternatives assessment goals — see the first tab for tools, and the second tab for data sources. You may also view more in-depth information on each tool and data source, or a side-by-side comparison of a set of tools or data sources, by selecting two or more items from the list below.

All tools and data sources included in the Tool Selector address chemical hazard assessment, and may address other comparative attributes. For information on tools with a primary focus on non-hazard comparative attributes such as cost/benefits and availability, life-cycle impacts, and materials management, please visit the Inventory of Non-Hazard Assessment Tools.

Each tool and data source has its benefits and limitations. The user of this toolbox needs to understand the capabilities of the tools and data sources to make the most informed decisions about conducting alternatives assessments.

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Human Health Effects:

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Physical and Chemical Properties:

Safety Information:

Comparative Attributes:

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Tools|Data Sources


Column Model ( Summary | Tool Website )

The Column Model was developed by the Institute for Occupational Safety and Health (IFA) of the German Social Accident Insurance as a tool for industry for identifying alternative substances. The tool allows for the comparison on chemicals/substances or materials/mixtures based on six hazard endpoints. Endpoints are compared individually and collectively, and the user makes the final evaluation.


Green Chemistry Assistant ( Summary | Tool Website )

The Green Chemistry Assistant allows users to manipulate and assess chemical reactions by determining atom economy, limiting reactant, theoretical yield, percent yield, and comparing chemical safety data. This tool is based on U.S. EPA's Green Chemistry Expert System SMART Module.


GreenScreen® for Safer Chemicals ( Summary | Tool Website )

GreenScreen® was developed by Clean Production Action to support the transition to safer chemicals and to support more informed decision-making on the use of chemicals in products and processes. GreenScreen® provides a rigorous comparative hazard assessment for evaluating alternatives to chemicals of concern based upon 18 hazard endpoints.


GreenScreen® List Translator (GSLT) ( Summary | Tool Website )

GSLT was developed by Clean Production Action as a rapid screening assessment tool for chemical substances. The screening evaluation results in three outcomes: of high concern, possibly of high concern, and unknown. GSLT is meant to prioritize chemicals for a more comprehensive assessment using the full GreenScreen® method.


KemI PRIO ( Summary | Tool Website )

PRIO was developed by the Swedish Chemical Inspectorate (KemI) to help eliminate high hazard chemicals from products to meet the Swedish government's goal of a "non-toxic environment" by 2020. PRIO contains a database of chemicals of high concern to human health and the environment, which are divided into "phase-out" or "priority risk reduction" chemicals. “Phase-out” chemicals should be avoided or substituted, and the tool provides a seven step process for identifying safer alternatives. For “priority risk reduction” chemicals, further assessments are recommended to ensure risk minimization.


MaterialIQ ( Summary | Tool Website )

MaterialIQ was developed to serve as a product design tool and as a product database of third party certified products. Users can select different methods for human health and ecotoxicity evaluations: GreenScreen List Translator, Scivera Lens or GreenScreen. Product evaluations can also be designed per criteria of a specific ecolabel. MaterialIQ was developed to improve transparency of hazard material usage throughout the supply chain.


OncoLogic 8.0 ( Summary | Tool Website )

OncoLogic 8.0 is a Windows software tool that predicts the potential carcinogenicity of metals, polymers, fibers, and organic chemicals. Evaluation is based upon structure activity relationship (SAR) analysis and a compilation of cancer data on 1,500 chemicals. This tool is intended to provide data on chemicals for which little or none exists.


Pollution Prevention Options Analysis System (P2OASys) ( Summary | Tool Website )

P2OASys was developed by the Toxic Use Reduction Institute (TURI) at the University of Massachusetts, Lowell to help companies assess unforeseen consequences of current alternative technologies. P2OAsys allows companies to assess environmental, worker, and public health impacts from alternative technologies. The tool automatically compares current processes to alternatives based on 11 endpoints using an aggregated score, which is dependent upon the proportion of chemical present.


Program for Assisting the Replacement of Industrial Solvents (PARIS) III ( Summary | Tool Website )

PARIS III was developed by the United States Environmental Protection Agency as a software tool to assist users in finding mixtures of solvents with specific properties that have reduced environmental impacts. Many solvents currently used in industrial processes have negative environmental impacts. PARIS III is designed to encourage technicians, engineers, and consultants to add more benign solvents to harmful ones to reduce the overall environmental impact without the need for equipment updates.


Quick Chemical Assessment Tool (QCAT) ( Summary | Tool Website )

Using GreenScreen® as a blueprint, QCAT was developed by the Washington State Department of Ecology to function as a simpler tool for smaller businesses. QCAT is a screening tool for evaluating chemicals/substances to determine their degree of toxicity and assess alternatives. Chemicals are rated based on an aggregated score of nine hazard endpoints, but relative toxicities can also be assessed based on individual endpoints.


SCIVERA LENS Chemical Safety Assessment System ( Summary | Tool Website )

This tool provides automated restricted substance list (RSL) review, hazard evaluation, exposure assessment (human health and environmental) and risk assessment over the life cycle of the product. As a tool for an alternatives assessment, user can process potential substitutes through the RSL, hazard, exposure, and risk steps to identify preferred alternatives. Scivera was developed for secure supplier product chemical data collection and comprehensive product evaluation.


SIN List and SINimilarity ( Summary | Tool Website )

The SIN List is an NGO List suggesting substances fulfilling REACH criteria for being “Substances of Very High Concern” (SVHCs). To date, the SIN List consists of some 800 CAS numbers divided into 31 groups. In the SIN List database, for every substance, there is information on hazardous properties, EU regulatory status, producing companies and production volume. When applicable, it also links to substitution case stories. SINimilarity is available through the SIN List database and can identify substances that are structurally similar to SIN List substances. The tool indicates whether the searched substance contains the same group-specific structural elements as SIN List substances and/or if it has structural similarity to any SIN List substances. SINimilarity includes a reference database of 80,000 substances that have been pre-registered under REACH.


SubSelect ( Summary | Tool Website )

The German Federal Environmental Agency's “Guide on Sustainable Chemicals” helps manufacturers, formulators, or end users of substances to put a greater emphasis on sustainability aspects in the selection of substances and use of chemicals. The guide furthermore assists companies in the implementation of the REACH task on the safe use of substances. With the Access-based file SubSelect, an electronic version of the guide is now available. SubSelect assists users in evaluating the sustainability of substances and mixtures.


UL The Wercs ( Summary | Tool Website )

UL The Wercs is a screening tool for product evaluation. The evaluation can be as complex as the user desires as the user selects the type and number of hazard endpoints/impacts to be evaluated: the user tailors the model. Multiple products can be compared graphically. The tool evaluates the products based on the presence of “chemicals of concern” in the product. The basis of chemicals of concern are “authoritative lists” or restricted substance lists developed by industry.

Tool Name Overall Applicability Goals Chemical Hazard Attributes Other Comparative Attributes User-Friendliness Fees User Expertise
CAMEO Chemicals
Chemical Entities of Biological Interest (ChEBI)
ChemSec Marketplace
ChemSec Textile Guide
Column Model
Compendium of Pesticide Common Names
EPA's Substance Registry Service Database
GESTIS Substance Database
Green Chemistry Assistant
GreenScreen® for Safer Chemicals
GreenScreen® List Translator (GSLT)
Hazardous Chemicals in Schools Database
Integrated Risk Information System (IRIS)
OncoLogic 8.0
OSHA Occupational Chemical Database
Pharos Project
Pollution Prevention Options Analysis System (P2OASys)
Program for Assisting the Replacement of Industrial Solvents (PARIS) III
Quick Chemical Assessment Tool (QCAT)
Safer Chemical Ingredients List (SCIL)
SCIVERA LENS Chemical Safety Assessment System
SIN List and SINimilarity
UL The Wercs

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